Thanks to forum user rudyvalencia, I have been able to boot the TV Guide Channel (from the floppy disk image discussed in the "Prevue Channel System Disk" topic) fully in E-UAE, an Amiga Emulator, and... it works! No video in the top, but the listing things scrolls around continuously with no listings, and the menus work... The ad menus are locked, however Rudy found that tin's backdoor to unlock the menus with no serial feed still works in the final Prevue software release from 1999. Go to the diagnostics screen, and type exclamation point twice, then press any key to leave the menu. The ad menus will then be unlocked.
Now, I could be wrong, but it sure LOOKS like we could get this to work without even having the genlock cards we previously thought were necessary. The guide seems to be fully working, with no data, and I would assume if we were to send it some of the serial commands that tin has reversed, it will come to life (I am currently trying to figure out how to send emulated serial commands, will try changing the date with mode K, etc.) Also, if you leave the guide running, it will start showing images from the /LOGOS directory of the ADF disk image.
Rudy has been working on figuring out how to properly boot this disk image for a little while, and he realized that it will only boot if the emulator is configured in a certain way. His configuration didn't work quite perfectly for me, (I think, it's kinda confusing) but here's the one that worked for me in Hi-Toro (probably several possibilities):
ROM: "Kickstart v2.04 rev 37.175 (1991)(Commodore)(A500+).rom"
Chip RAM: 1.0MB
Fast RAM: 8.0MB
Slow RAM: 0.5MB
CPU: 68000
Chipset: ECS
Mode: NTSC
Center horizontal: Simple
Center vertical: Simple
DF0: PREVUE.ADF
If you want to try this out, I would recommend using the E-UAE Amiga emulator on Mac/Linux or WinUAE on Windows, and I will send anyone the ADF who wants it. I will post videos and screenshots soon, for now here are the two screenshots Rudy provided me with:

